Recent evidence showed that LDL oxidation occurs not within the interstitial fluid of atherosclerotic lesions but within lysosomes in macrophages in atherosclerotic lesions. Most important, the study found that this oxidative modification was inhibited by the drug chloroquine, which increases the pH of lysosomes, as oxidation can be promoted by acidic pH (1, 2)
1) Low Density Lipoprotein Undergoes Oxidation Within Lysosomes in Cells, Yichuan Wen and David S. Leake, Circ. Res. 2007;100;1337-1343; em http://circres.ahajournals.org/cgi/content/full/100/9/1337
2) Carlos ETB Monteiro, Acidic environment evoked by chronic stress: A novel mechanism to explain atherogenesis. Available from Infarct Combat Project, January 28, 2008 at http://www.infarctcombat.org/AcidityTheory.pdf
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